2/22/2023 0 Comments Incontrol acs![]() ![]() The GG genotype carriers in ACS patients had worse clinical outcomes compared with those carrying CC or CG genotype. GG genotype of MIF gene rs2070766 was associated with a higher risk of ACS in a Chinese population. During the follow-up period of 25 months, Kaplan-Meier curves demonstrated that ACS patients carrying GG phenotype developed more MACE compared to CC or CG carriers ( p < 0.05). The nomogram model had a good discrimination with an area under the curve of 0.781 (95% CI: 0.759–0.804), concordance index of 0.784 (95% CI: 0.762–0.806) and well-fitted calibration. Using MIF rs2070766 genotypes and clinical factors, we developed a nomogram model to predict risk of ACS. Multivariate logistic regression analysis revealed that individuals with mutant GG genotype had a 1.7-fold higher risk of ACS compared with individuals with CC or CG genotypes. The frequency of rs2070766 GG genotype was higher in ACS patients than in control subjects (6.2 vs 3.8%, p = 0.034). ![]() Major adverse cardiovascular events (MACE) were monitored during a follow-up period. A nomogram model using MIF genetic variation and clinical variables was established to predict risk of ACS. All participants were genotyped for the single nucleotide polymorphism (SNP) of MIF gene rs2070766 using SNPscan™. This study involved in 963 ACS patients and 932 control subjects from a Chinese population. We investigated an association between the polymorphism of MIF gene rs2070766 and acute coronary syndromes (ACS) and the predictive value of MIF gene variation in clinical outcomes. Genetic variation of macrophage migration inhibitory factor ( MIF) gene has been linked to coronary artery disease. 5People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.4Xinjiang Key Laboratory of Medical Animal Model Research, Clinical Medical Research Institute of Xinjiang Medical University, Urumqi, China.3Xinjiang Key Laboratory of Cardiovascular Disease Research, Clinical Medical Research Institute of Xinjiang Medical University, Urumqi, China.2Rehabilitation Department of First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.1State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.Jin-Yu Zhang 1,2 †, Qian Zhao 1,3 †, Fen Liu 1,3, De-Yang Li 1, Li Men 1, Jun-Yi Luo 1,3, Ling Zhao 1,4, Xiao-Mei Li 1,3*, Xiao-Ming Gao 1,3,4* and Yi-Ning Yang 1,3,5* ![]()
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